Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish
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چکیده
منابع مشابه
Down - Regulation of Human Protein Kinase C a Is Associated With Terminal Neutrophil Differentiation
We have established an RNase protection method to quantify the expression of mRNA for the human protein kinase C (PK-C) isoforms a, p1,82, and y. This was used to investigate whether each isoform is differentially expressed during the differentiation of hematopoietic cells. Myeloid and lymphoid cells express PK-C a, 81, and 82 mRNAs in various proportions. PK-C y mRNA was detected in human brai...
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C/EBPε, a member of the CCAAT/enhancer binding protein (C/EBP) family of transcription factors, is exclusively expressed in myeloid cells and regulates transition from the promyelocytic stage to the myelocytic stage of neutrophil development, being indispensable for secondary and tertiary granule formation. Knowledge concerning the functional role of C/EBPε posttranslational modifications is li...
متن کاملDown-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation.
We have established an RNase protection method to quantify the expression of mRNA for the human protein kinase C (PK-C) isoforms alpha, beta 1, beta 2, and gamma. This was used to investigate whether each isoform is differentially expressed during the differentiation of hematopoietic cells. Myeloid and lymphoid cells express PK-C alpha, beta 1, and beta 2 mRNAs in various proportions. PK-C gamm...
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0022-2836/$ see front matter © 2009 E Parkinson's disease (PD) is associated with the deposition of fibrillar aggregates of the protein α-synuclein (αS) in neurons. Intramolecular contacts between the acidic C-terminal tail of αS and its N-terminal region have been proposed to regulate αS aggregation, and two originally described PD mutations, A30P and A53T, reportedly reduce such contacts. We ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2021
ISSN: 0887-6924,1476-5551
DOI: 10.1038/s41375-021-01121-8